Adrenomedullin
Also known as: AM, ADM
Adrenomedullin is a 52-amino-acid peptide hormone derived from a precursor protein that also produces the peptide PAMP. It acts as a potent vasodilator and plays a role in maintaining fluid and electrolyte balance. In the kidney, it functions as a diuretic and natriuretic agent while inhibiting aldosterone secretion. Adrenomedullin is linked to processes such as blood vessel growth and metabolic signaling in obesity.
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Overview
Mammalian protein found in humans
Adrenomedullin (ADM) is a peptide hormone that plays an important role in various physiological processes throughout the human body. Initially discovered in 1993 from a pheochromocytoma, a tumor of the adrenal medulla, this 52-amino acid peptide is now recognized for its diverse effects, including vasodilation, regulation of blood pressure, and maintenance of the vascular system. ADM is widely expressed in tissues and also found in the circulation, exerting its influence on the cardiovascular, lymphatic, and endocrine systems, as well as demonstrating anti-inflammatory and tissue-protective properties.
Mechanism of Action
Adrenomedullin acts through receptor complexes composed of the calcitonin receptor-like receptor (CALCRL) and either RAMP2 or RAMP3 proteins on cell surfaces. In blood vessels, this interaction leads to smooth muscle relaxation and vessel dilation. In the kidney, it promotes sodium and water excretion and suppresses aldosterone production. Research has shown that adrenomedullin can also interfere with insulin-receptor signaling in endothelial cells through the action of the phosphatase PTP1B.
Research History
Adrenomedullin was discovered in 1993 from tissue obtained from a pheochromocytoma, a tumor of the adrenal medulla, which inspired its name. Initial studies identified it as a significant vasodilatory hormone active in the cardiovascular system. Further research expanded its known roles to include kidney function regulation, blood vessel development, and contributions to metabolic processes, such as those related to insulin resistance in obesity highlighted in 2025.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Adrenomedullin (also known as AM, ADM) is studied within the metabolic health research community. Multifunctional peptide with vasodilatory, anti-inflammatory, and angiogenic properties studied across cardiovascular and sepsis models.
Last updated October 28, 2026
Research status: emerging. Adrenomedullin appears across metabolic health research forums and academic literature. Researchers note this compound falls in the metabolic category.
Last updated October 28, 2026
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