APC (Activated Protein C)
Also known as: drotrecogin alfa, xigris, protein c fragment
Anticoagulant serine protease studied for cytoprotective and anti-inflammatory effects in critical illness.
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Overview
Pharmaceutical drug
Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Drotrecogin alpha (activated) belongs to the class of serine proteases. Drotrecogin alfa has not been found to improve outcomes in people with severe sepsis. The manufacturer's aggressive strategies in marketing its use in severe sepsis have been criticized. On October 25, 2011, Eli Lilly & Co. withdrew Xigris from the market after a major study showed no efficacy for the treatment of sepsis.
Mechanism of Action
Drotrecogin alfa (activated) (Xigris, marketed by Eli Lilly and Company) is a recombinant form of human activated protein C that has anti-thrombotic, anti-inflammatory, and profibrinolytic properties. Drotrecogin alpha (activated) belongs to the class of serine proteases. Drotrecogin alfa has not been found to improve outcomes in people with severe sepsis. The manufacturer's aggressive strategies in marketing its use in severe sepsis have been criticized. On October 25, 2011, Eli Lilly & Co. withdrew Xigris from the market after a major study showed no efficacy for the treatment of sepsis.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
APC (Activated Protein C) (also known as drotrecogin alfa, xigris) is studied within the immune modulation research community. Anticoagulant serine protease studied for cytoprotective and anti-inflammatory effects in critical illness.
Last updated October 28, 2026
Research status: limited. APC (Activated Protein C) appears across immune modulation research forums and academic literature. Researchers note this compound falls in the immune category.
Last updated October 28, 2026
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