Charybdotoxin
Also known as: ChTX, alpha-KTx 1.1, scorpion ChTX
Scorpion-derived potassium channel blocker used as research probe for Kv1.2/1.3 and BK channel characterization.
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Charybdotoxin - Research Images
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Overview
Chemical compound, scorpion neurotoxin
Charybdotoxin (ChTX) is a 37 amino acid neurotoxin from the venom of the scorpion Leiurus quinquestriatus hebraeus (deathstalker) that blocks calcium-activated potassium channels. This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus. It is named after Charybdis, a sea monster from Greek myth.
Mechanism of Action
Charybdotoxin (ChTX) is a 37 amino acid neurotoxin from the venom of the scorpion Leiurus quinquestriatus hebraeus (deathstalker) that blocks calcium-activated potassium channels. This blockade causes hyperexcitability of the nervous system. It is a close homologue of agitoxin and both toxins come from Leiurus quinquestriatus hebraeus. It is named after Charybdis, a sea monster from Greek myth.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Charybdotoxin (also known as ChTX, alpha-KTx 1.1) is studied within the peptide research community. Scorpion-derived potassium channel blocker used as research probe for Kv1.2/1.3 and BK channel characterization.
Last updated October 28, 2026
Research status: limited. Charybdotoxin appears across peptide research forums and academic literature. Researchers note this compound falls in the other category.
Last updated October 28, 2026
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