Cortistatin
Also known as: CST-14, cst14, cortistatin-14
Cortistatin is a neuropeptide best known in its 14 amino acid form, cortistatin-14, which is cut from a larger human precursor protein. It shares its receptor family with somatostatin and is studied in neuroscience for its calming effect on cortical activity and its links to sleep regulation.
Quick Reference
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Overview
Index of chemical compounds with the same name
Cortistatin can refer to:Cortistatin (neuropeptide), a peptide hormone Cortistatins, a class of steroids applied against angiogenesis
Mechanism of Action
Cortistatin signals through somatostatin receptors, where it can suppress forskolin driven cAMP production, and it also acts as a ligand for MRGPRX2 on mast cells. Through these pathways it is associated in research models with reduced neuronal excitability and sleep modulating effects.
Research History
Cortistatin entered the literature as a cortex associated neuropeptide related to somatostatin. Research showed that it binds all somatostatin receptor subtypes and can lower cAMP production in responding cells, and later work added the mast cell receptor MRGPRX2 to its known targets.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Cortistatin (also known as CST-14, cst14) is studied within the cognitive function and neuroprotection research community. Neuropeptide sharing receptors with somatostatin, studied for sleep regulation and cortical excitability.
Last updated October 28, 2026
Research status: limited. Cortistatin appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
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