Difelikefalin
Also known as: CR845, kappa opioid agonist, kappa opioid peptide peripherally restricted
Peripherally restricted kappa-opioid receptor agonist studied for pruritus and inflammation without central side effects.
Quick Reference
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Overview
Chemical compound
Difelikefalin, sold under the brand name Korsuva, is an opioid peptide used for the treatment of moderate to severe itch. It acts as a peripherally-restricted, highly selective agonist of the κ-opioid receptor (KOR).
Mechanism of Action
Difelikefalin, sold under the brand name Korsuva, is an opioid peptide used for the treatment of moderate to severe itch. It acts as a peripherally-restricted, highly selective agonist of the κ-opioid receptor (KOR).
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Difelikefalin (also known as CR845, kappa opioid agonist) is studied within the immune modulation research community. Peripherally restricted kappa-opioid receptor agonist studied for pruritus and inflammation without central side effects.
Last updated October 28, 2026
Research status: active. Difelikefalin appears across immune modulation research forums and academic literature. Researchers note this compound falls in the immune category.
Last updated October 28, 2026
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