FOXO4-DRI
Also known as: foxo4 dri, foxo4-d-ret-i, senolytic peptide
D-retro-inverso peptide targeting FOXO4-p53 interaction, studied for selective clearance of senescent cells.
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Overview
Pharmaceutical compound
FOXO4-DRI is a synthetic peptide derivative that is described as an all D-enantiomer retro-inverso peptide It blocks the activity of Forkhead box protein O4 (FOXO4), a transcription factor which is elevated in senescent cells, and helps maintain their viability. Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer. It has the sequence H-ltlrkepaseiaqsileaysqngwanrrsggkrppprrrqrrkkrg-OH.
Mechanism of Action
FOXO4-DRI is a synthetic peptide derivative that is described as an all D-enantiomer retro-inverso peptide It blocks the activity of Forkhead box protein O4 (FOXO4), a transcription factor which is elevated in senescent cells, and helps maintain their viability. Blocking FOXO4, which inhibits the activation of P53, causes senescent cells to undergo apoptosis by P53 activation, without affecting healthy cells around them, and has anti-aging effects which may have potential applications in the treatment of numerous age-related diseases, as well as an adjunct to treatment for certain forms of cancer.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
FOXO4-DRI (also known as foxo4 dri, foxo4-d-ret-i) is studied within the longevity and anti-aging research community. D-retro-inverso peptide targeting FOXO4-p53 interaction, studied for selective clearance of senescent cells.
Last updated October 28, 2026
Research status: emerging. FOXO4-DRI appears across longevity and anti-aging research forums and academic literature. Researchers note this compound falls in the anti aging category.
Last updated October 28, 2026
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