Galanin-like Peptide
Also known as: GALP, galanin-like peptide
Galanin-like peptide, or GALP, is a 60 amino acid hypothalamic neuropeptide. It binds the galanin receptor family and is studied in energy balance, hormone release, and skin blood vessel responses.
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Overview
Protein family
Galanin-like peptide (GALP) is a neuropeptide present in humans and other mammals. It is a 60-amino acid polypeptide produced in the arcuate nucleus of the hypothalamus and the posterior pituitary gland. It is involved in the regulation of appetite and may also have other roles such as in inflammation, sex behavior, and stress.
Mechanism of Action
GALP binds the G protein coupled galanin receptors GALR1, GALR2, and GALR3 and participates in central control processes, including regulation of gonadotropin-releasing hormone release. In skin microvessels it shows vessel narrowing and anti-swelling activity that does not appear to run through GALR1 or GALR2, and laboratory work reports activity against Gram-negative bacteria through disruption of their membranes.
Research History
GALP was identified as a relative of galanin that shares its receptor family while coming from its own gene and precursor. Its presence in the hypothalamus placed it early in research on brain control of gonadotropin-releasing hormone release.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Galanin-like Peptide (also known as GALP, galanin-like peptide) is studied within the metabolic and weight management research community. Hypothalamic peptide that binds galanin receptors and regulates energy balance, GnRH neurons, and leptin signaling.
Last updated October 28, 2026
Research status: limited. Galanin-like Peptide appears across metabolic and weight management research forums and academic literature. Researchers note this compound falls in the weight loss category.
Last updated October 28, 2026
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