Intermedin
Also known as: adrenomedullin 2, AM2, IMD
Intermedin, also known as adrenomedullin 2 or AM2, is a 47 amino acid peptide belonging to the calcitonin family, documented in UniProt under accession Q7Z4H4. It is relevant in cardiovascular and gastrointestinal research, including blood pressure and heart studies. Its molecular formula is C219H350N68O67S3, and it has a mass near 5103.78 daltons.
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Overview
Family of peptide hormones and neuropeptides
The melanocyte-stimulating hormones, known collectively as MSH, also known as melanotropins or intermedins, are a family of peptide hormones and neuropeptides consisting of α-melanocyte-stimulating hormone (α-MSH), β-melanocyte-stimulating hormone (β-MSH), and γ-melanocyte-stimulating hormone (γ-MSH) that are produced by cells in the pars intermedia of the anterior lobe of the pituitary gland.
Mechanism of Action
Intermedin engages receptor complexes built from CALCRL paired with RAMP proteins, with the CALCRL-RAMP3 pairing the most studied. This interaction activates the cyclic AMP signaling pathway in target cells, which underlies its regulatory roles in both gastrointestinal and cardiovascular activity.
Research History
Intermedin was identified as a relative of adrenomedullin, the peptide it most closely resembles, and it continues to be referred to by both names. Rat and mouse variants of this peptide are also cataloged in UniProt alongside the human form.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Intermedin (also known as adrenomedullin 2, AM2) is studied within the metabolic health research community. Calcitonin family peptide with cardioprotective and vasodilatory properties studied in heart failure models.
Last updated October 28, 2026
Research status: emerging. Intermedin appears across metabolic health research forums and academic literature. Researchers note this compound falls in the metabolic category.
Last updated October 28, 2026
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