Kisspeptin-10
Also known as: kisspeptin 10, kp-10, kp10, metastin 45-54, KP-10
Kisspeptin-10 is the terminal 10 amino acids of the kisspeptin family, also known as metastin 45-54 and KP-10. It is cataloged under the human KISS1 entry Q15726 in UniProt, with a mass near 1303.44 daltons. It is primarily researched within the scope of the reproductive hormone axis.
Quick Reference
Kisspeptin-10 - Research Images
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Mechanism of Action
Kisspeptin-10 binds the receptor KISS1R, also called GPR54, on GnRH neurons in the hypothalamus. This interaction activates Gq signaling: phospholipase C processes PIP2, intracellular calcium rises, potassium channels close and cation channels open, and the neuron fires, leading to GnRH release. A second, slower route through beta-arrestin triggers the MAPK cascade and ERK1 and ERK2 phosphorylation.
Research History
Kisspeptin-10, derived from the KISS1 precursor, is the shortest commonly studied member of the kisspeptin family. The same decapeptide sequence is cataloged in rat, mouse, and macaque records as well as the human entry.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Kisspeptin-10 (also known as kisspeptin 10, kp-10) is studied within the immune modulation research community. C-terminal fragment of kisspeptin studied for GnRH pulse stimulation and reproductive axis regulation.
Last updated October 28, 2026
Research status: active. Kisspeptin-10 appears across immune modulation research forums and academic literature. Researchers note this compound falls in the immune category.
Last updated October 28, 2026
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