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Anti-Aging / LongevityEmerging Research Fact-Checked (10 sources)

Klotho

Also known as: alpha-klotho, KL protein, soluble klotho, FGF23 co-receptor

Klotho is a large human protein examined in aging and metabolic research. Database records pair it with FGF23 signaling and note enzyme activity toward selected steroid glucuronide compounds in laboratory systems. A form freed by cleavage of the membrane protein is discussed as a circulating factor connected to insulin and IGF1 pathway activity.

Klotho research vial - Peptide Stores Online

Quick Reference

FormulaC5183H7751N1359O1416S29
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Klotho - Research Images

PSO vial render · Scientific images from Wikipedia · Tap to enlarge

Mechanism of Action

Klotho enables contact between FGF23 and FGFR1, a pairing tied to renal control of phosphate and vitamin D status. Test system work also records breakdown of several steroid beta D glucuronides. Once the membrane form is cut, the released portion can circulate and is described in relation to insulin and IGF1 linked signaling.

Research History

Scientific attention first centered on Klotho through its links to kidney phosphate handling and vitamin D balance. Later curation added details on activity seen in vitro and on its role in helping FGF23 meet its receptor. Ongoing literature keeps placing it where mineral control, liver signaling, and gut pathway discussions overlap.

Research Summaries - Plain English
What published studies found, rewritten so anyone can understand. No jargon, no outbound links.

What Researchers Are Saying

Community Reports - Not Medical Advice

The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.

research summaryvia Research Literature

Klotho (also known as alpha-klotho, KL protein) is studied within the longevity and anti-aging research community. Anti-aging hormone/enzyme studied for cognitive function, kidney health, and extension of healthspan in preclinical models.

Last updated October 28, 2026

research statusvia Community Aggregation

Research status: emerging. Klotho appears across longevity and anti-aging research forums and academic literature. Researchers note this compound falls in the anti aging category.

Last updated October 28, 2026

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