MK-677
Also known as: mk677, ibutamoren, ibutamoren mesylate, nutrobal, L-163,191
Non-peptide GH secretagogue / ghrelin mimetic studied for GH and IGF-1 elevation; often grouped with SARMs.
Quick Reference
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Overview
Experimental drug
Ibutamoren is a potent, long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. It has been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones while also raising cortisol levels.
Mechanism of Action
Binds ghrelin receptor, stimulates GH and IGF-1, increases appetite and promotes anabolic effects via oral route.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
MK-677 (also known as mk677, ibutamoren) is studied within the growth hormone axis and body composition research community. Non-peptide GH secretagogue / ghrelin mimetic studied for GH and IGF-1 elevation; often grouped with SARMs.
Last updated October 28, 2026
Research status: active. MK-677 appears across growth hormone axis and body composition research forums and academic literature. Researchers note this compound falls in the growth hormone category.
Last updated October 28, 2026
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