Nesfatin-1
Also known as: nesfatin, NUCB2-derived peptide
Nesfatin-1 is an 82 amino acid peptide fragment from the NUCB2 protein, cataloged in UniProt under accession P80303, with a mass near 9551.77 daltons. It is prominently studied as a regulator of appetite that reduces food intake. The NUCB2 protein also has a calcium binding function, which aligns with the family characteristics reflected in its name.
Quick Reference
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Overview
Neuropeptide produced in the hypothalamus of mammals
Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Increased nesfatin-1 in the hypothalamus contributes to diminished hunger, a 'sense of fullness', and a potential loss of body fat and weight.
Mechanism of Action
In the hypothalamus, nesfatin-1 modulates food intake and energy homeostasis through pathways independent of leptin. It also influences blood pressure through effects on peripheral arterial resistance, and in intestinal epithelial cells it is linked to restraining hepatic glucose production through the MC4R receptor, elevating cyclic AMP and GLP-1 levels. Additionally, the NUCB2 protein activates the G protein subunit GNAI3 as a non-receptor exchange factor.
Research History
Identified as the fragment of NUCB2 linked to appetite control, nesfatin-1 has been studied across species, with records for humans, mice, rats, and fruit flies. Its role in appetite involves hypothalamic control of hunger and energy balance without dependence on leptin.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Nesfatin-1 (also known as nesfatin, NUCB2-derived peptide) is studied within the metabolic and weight management research community. Hypothalamic peptide studied for satiety signaling and glucose homeostasis.
Last updated October 28, 2026
Research status: emerging. Nesfatin-1 appears across metabolic and weight management research forums and academic literature. Researchers note this compound falls in the weight loss category.
Last updated October 28, 2026
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