Neuropeptide Y
Also known as: NPY, npy peptide, neuropeptide-Y, neuropeptide tyrosine
Neuropeptide Y, or NPY, is a 36 amino acid signaling peptide abundant in the brain. It is studied in connection with eating behavior, gut secretion control, and stress related brain circuits. UniProt lists its human form under accession P01303 with a mass near 4272.66 daltons.
Quick Reference
Neuropeptide Y - Research Images
PSO vial render · Scientific images from Wikipedia · Tap to enlarge
Overview
Mammalian protein found in Homo sapiens
Neuropeptide Y (NPY) is a 36-amino acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. It is secreted alongside other neurotransmitters such as GABA and glutamate.
Mechanism of Action
NPY binds mainly to the Y1 and Y2 receptors, which are G protein coupled receptors that lower cyclic AMP production inside target cells. Receptor activation can also raise intracellular calcium levels. Through these pathways NPY influences food intake signals and helps set antisecretory tone and contractility in the colon.
Research History
NPY takes its name from its tyrosine rich makeup, reflected in its alias neuropeptide tyrosine. It became a central molecule in appetite research after work showed it acts as a strong stimulator of food intake through its brain receptors.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Neuropeptide Y (also known as NPY, npy peptide) is studied within the cognitive function and neuroprotection research community. Abundant brain neuropeptide studied for appetite regulation, stress resilience, and mood modulation.
Last updated October 28, 2026
Research status: limited. Neuropeptide Y appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
What Do You Think of This Peptide?
Share your opinion or research experience with Neuropeptide Y. Comments are reviewed before appearing.