Neurotensin
Also known as: NT, neurotensin 1-13, neurotensin-13, NT-13
Neurotensin is a 13 amino acid peptide found in both neural and gastrointestinal tissues, documented in UniProt under accession P30990 for the human form. It is studied in fat metabolism and smooth muscle regulation, and its receptor NTSR1 attracts research interest because several tumor types show high levels of it. Neurotensin has a mass near 1689.96 daltons.
Quick Reference
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Overview
Protein family
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. Neurotensin was first isolated from extracts of bovine hypothalamus based on its ability to cause a visible vasodilation in the exposed cutaneous regions of anesthetized rats.
Mechanism of Action
Neurotensin functions through receptors like NTSR1. It is associated with smooth muscle contraction in the gut and with regulation of fat metabolism, and it acts in both endocrine and paracrine modes, signaling through the bloodstream or directly to adjacent cells. In the brain it serves as a neuromodulator.
Research History
Neurotensin is named for its presence in neural tissue, and it is referred to as NT or NT-13 across the literature. Research on it has spanned brain functions, gut physiology, and receptor targeted studies focusing on NTSR1.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Neurotensin (also known as NT, neurotensin 1-13) is studied within the cognitive function and neuroprotection research community. Brain-gut neuropeptide that modulates dopaminergic transmission; researched in psychosis, pain, and temperature regulation.
Last updated October 28, 2026
Research status: active. Neurotensin appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
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