Nociceptin
Also known as: OFQ, orphanin FQ, N/OFQ
Endogenous opioid-like neuropeptide studied for pain modulation, anxiety, and addiction pathways.
Quick Reference
Nociceptin - Research Images
PSO vial render · Scientific images from Wikipedia · Tap to enlarge
Overview
Neuropeptide chemical compound
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor. Nociceptin acts as a potent anti-analgesic, effectively counteracting the effect of pain-relievers; its activation is associated with brain functions such as pain sensation and fear learning.
Mechanism of Action
Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor. Nociceptin acts as a potent anti-analgesic, effectively counteracting the effect of pain-relievers; its activation is associated with brain functions such as pain sensation and fear learning.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Nociceptin (also known as OFQ, orphanin FQ) is studied within the cognitive function and neuroprotection research community. Endogenous opioid-like neuropeptide studied for pain modulation, anxiety, and addiction pathways.
Last updated October 28, 2026
Research status: active. Nociceptin appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
What Do You Think of This Peptide?
Share your opinion or research experience with Nociceptin. Comments are reviewed before appearing.