Orexin B
Also known as: hypocretin-2, orexin-B, HCRT2
Hypothalamic neuropeptide co-released with orexin A that modulates wakefulness and energy balance.
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Overview
Neuropeptide that regulates arousal, wakefulness, and appetite
Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone, is caused by a lack of orexin in the brain due to destruction of the cells that produce it.
Mechanism of Action
Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. It exists in the forms of orexin-A and orexin-B. The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone, is caused by a lack of orexin in the brain due to destruction of the cells that produce it.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Orexin B (also known as hypocretin-2, orexin-B) is studied within the cognitive function and neuroprotection research community. Hypothalamic neuropeptide co-released with orexin A that modulates wakefulness and energy balance.
Last updated October 28, 2026
Research status: active. Orexin B appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
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