Osteocalcin
Also known as: bone gla protein, BGP, osteocalcin hormone
Osteocalcin, also called bone Gla protein, is a 49 amino acid protein made by bone forming cells. It is one of the main organic components of bone matrix, and its uncarboxylated form is studied as a hormone that links bone to energy metabolism and brain development.
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Overview
Mammalian protein found in humans
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein.
Mechanism of Action
After gamma-carboxylation, osteocalcin binds strongly to apatite and calcium in bone and helps limit bone formation without blocking resorption or mineralization. The uncarboxylated form acts through receptors including GPRC6A in the testes and GPR158 in the brain, where signaling is linked to testosterone synthesis enzymes, monoamine neurotransmitter production, and protection of hippocampal neurons in research models.
Research History
Osteocalcin was first studied as a structural bone protein that binds calcium and apatite after gamma-carboxylation. Research later expanded when the uncarboxylated form was found to act like a hormone, with reported roles in insulin handling, testosterone production, and fetal and adult brain function.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Osteocalcin (also known as bone gla protein, BGP) is studied within the longevity and anti-aging research community. Bone-derived hormone studied for muscle, brain, and metabolic function in aging models.
Last updated October 28, 2026
Research status: emerging. Osteocalcin appears across longevity and anti-aging research forums and academic literature. Researchers note this compound falls in the anti aging category.
Last updated October 28, 2026
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