PACAP-38
Also known as: pituitary adenylate cyclase activating polypeptide, PACAP, pituitary adenylate cyclase-activating peptide, ADCYAP1
Neuropeptide with potent neuroprotective and anti-inflammatory properties; researched in neurodegeneration and stress models.
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Overview
Protein-coding gene in the species Homo sapiens
Pituitary adenylate cyclase-activating polypeptide, also known as PACAP, is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to the vasoactive intestinal peptide receptor and the PACAP receptor.
Mechanism of Action
Pituitary adenylate cyclase-activating polypeptide, also known as PACAP, is a protein that in humans is encoded by the ADCYAP1 gene. PACAP is similar to vasoactive intestinal peptide. One of its effects is to stimulate enterochromaffin-like cells. It binds to the vasoactive intestinal peptide receptor and the PACAP receptor.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
PACAP-38 (also known as pituitary adenylate cyclase activating polypeptide, PACAP) is studied within the cognitive function and neuroprotection research community. Neuropeptide with potent neuroprotective and anti-inflammatory properties; researched in neurodegeneration and stress models.
Last updated October 28, 2026
Research status: emerging. PACAP-38 appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
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