Pancreatic Polypeptide
Also known as: PP, pancreatic PP, PPY
Pancreatic peptide that regulates appetite and gastric acid secretion; studied as biomarker and satiety target.
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Overview
Hormone produced by the pancreas
Pancreatic polypeptide (PP) is a hormone that in humans is encoded by the gene PPY. This polypeptide is secreted by PP cells in the endocrine pancreas. It regulates pancreatic secretion activities, and impacts liver glycogen storage and gastrointestinal secretion. Its secretion may be impacted by certain endocrine tumours.
Mechanism of Action
Pancreatic polypeptide (PP) is a hormone that in humans is encoded by the gene PPY. This polypeptide is secreted by PP cells in the endocrine pancreas. It regulates pancreatic secretion activities, and impacts liver glycogen storage and gastrointestinal secretion. Its secretion may be impacted by certain endocrine tumours.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Pancreatic Polypeptide (also known as PP, pancreatic PP) is studied within the metabolic health research community. Pancreatic peptide that regulates appetite and gastric acid secretion; studied as biomarker and satiety target.
Last updated October 28, 2026
Research status: limited. Pancreatic Polypeptide appears across metabolic health research forums and academic literature. Researchers note this compound falls in the metabolic category.
Last updated October 28, 2026
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