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CognitiveEmerging Research

PE22-28

Also known as: spadin analogue, TREK-1 blocker peptide, spadin, prosaposin-derived peptide, TREK-1 blocker

Antidepressant peptide derived from the neurotensin sortilin propeptide; studied for rapid-acting antidepressant properties without SSRI mechanisms.

PE22-28 research vial - Peptide Stores Online

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PE22-28 - Research Images

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Mechanism of Action

Antidepressant peptide derived from the neurotensin sortilin propeptide; studied for rapid-acting antidepressant properties without SSRI mechanisms.

Detailed mechanism data is being compiled. Check PubMed for the latest research.
Research Summaries - Plain English
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What Researchers Are Saying

Community Reports - Not Medical Advice

The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.

research summaryvia Research Literature

PE22-28 (also known as spadin analogue, TREK-1 blocker peptide) is studied within the cognitive function and neuroprotection research community. Antidepressant peptide derived from the neurotensin sortilin propeptide; studied for rapid-acting antidepressant properties without SSRI mechanisms.

Last updated October 28, 2026

research statusvia Community Aggregation

Research status: emerging. PE22-28 appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.

Last updated October 28, 2026

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