Peptide YY
Also known as: PYY, pyy 3-36, pyy3-36, peptide YY 3-36, PYY 3-36
Peptide YY, or PYY, is a 36 amino acid gut hormone released after meals, recorded in UniProt under accession P10082. A shortened form, PYY 3-36, is the version most discussed in appetite research. The full peptide has a recorded mass near 4409.87 daltons.
Quick Reference
Peptide YY - Research Images
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Overview
Peptide released from cells in the ileum and colon in response to feeding
Peptide YY (PYY), also known as peptide tyrosine tyrosine, is a peptide that in humans is encoded by the PYY gene. Peptide YY is a short peptide released from cells in the ileum and colon in response to feeding. In the blood, gut, and other elements of periphery, PYY acts to reduce appetite; similarly, when injected directly into the central nervous system, PYY is also anorexigenic, i.e., it reduces appetite.
Mechanism of Action
PYY binds the neuropeptide Y receptors NPY1R and NPY2R, and also NPY5R. These receptors lower cyclic AMP production and raise intracellular calcium. Through NPY2R on hypothalamic circuits, PYY 3-36 is linked to reduced appetite and food intake, and in the gut the peptide restrains pancreatic secretion and helps set colonic antisecretory tone and contractility.
Research History
PYY is named for its two signature tyrosine residues, reflected in its longer name, peptide tyrosine tyrosine. It belongs to the same peptide family as neuropeptide Y and is produced in the intestine, with the 3-36 form arising when the first two residues are trimmed away.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Peptide YY (also known as PYY, pyy 3-36) is studied within the metabolic and weight management research community. Gut-derived peptide studied for appetite suppression and regulation of energy intake.
Last updated October 28, 2026
Research status: active. Peptide YY appears across metabolic and weight management research forums and academic literature. Researchers note this compound falls in the weight loss category.
Last updated October 28, 2026
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