Phoenixin
Also known as: PHX, phoenixin-14
Neuropeptide studied for its role in anxiety, reproductive function, and neuroinflammation modulation.
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Overview
Protein-coding gene in the species Homo sapiens
Small integral membrane protein 20 (SMIM20) is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin (PNX) which was discovered for the first time in 2013 in rodent sensory ganglia. Two alternate cleavage sites within SMIM20 results in two different phoenixin products, Phoenixin-14 (PNX-14) and Phoenixin-20 (PNX-20).
Mechanism of Action
Small integral membrane protein 20 (SMIM20) is a protein that in humans is encoded by the SMIM20 gene. SMIM20 acts as a prohormone to the peptide hormone phoenixin (PNX) which was discovered for the first time in 2013 in rodent sensory ganglia. Two alternate cleavage sites within SMIM20 results in two different phoenixin products, Phoenixin-14 (PNX-14) and Phoenixin-20 (PNX-20).
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Phoenixin (also known as PHX, phoenixin-14) is studied within the cognitive function and neuroprotection research community. Neuropeptide studied for its role in anxiety, reproductive function, and neuroinflammation modulation.
Last updated October 28, 2026
Research status: emerging. Phoenixin appears across cognitive function and neuroprotection research forums and academic literature. Researchers note this compound falls in the cognitive category.
Last updated October 28, 2026
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