Rapamycin
Also known as: sirolimus, rapamune
mTOR inhibitor extensively studied in longevity research; shown to extend lifespan in multiple model organisms.
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Overview
Pharmaceutical drug
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity.
Mechanism of Action
Sirolimus, also known as rapamycin and sold under the brand name Rapamune among others, is a macrolide compound that is used to coat coronary stents, prevent organ transplant rejection, treat a rare lung disease called lymphangioleiomyomatosis, and treat perivascular epithelioid cell tumour (PEComa). It has immunosuppressant functions in humans and is especially useful in preventing the rejection of kidney transplants. It is a mammalian target of rapamycin (mTOR) kinase inhibitor that reduces the sensitivity of T cells and B cells to interleukin-2 (IL-2), inhibiting their activity.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Rapamycin (also known as sirolimus, rapamune) is studied within the longevity and anti-aging research community. mTOR inhibitor extensively studied in longevity research; shown to extend lifespan in multiple model organisms.
Last updated October 28, 2026
Research status: active. Rapamycin appears across longevity and anti-aging research forums and academic literature. Researchers note this compound falls in the anti aging category.
Last updated October 28, 2026
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