Thymosin Beta-4 Fragment
Also known as: tβ4 fragment, ac-SDKP, ac sdkp, N-acetyl-seryl-aspartyl-lysyl-proline
Tetrapeptide fragment of Thymosin Beta-4 studied for cardiac and tissue protective effects.
Quick Reference
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Overview
Pharmaceutical compound
Ac-SDKP is an endogenous tetrapeptide derivative that is the N-acetylated derivative of the fragment composed of amino acids 1-4 derived from cleavage of the N-terminus of the signalling factor thymosin beta-4 by the enzyme prolyl oligopeptidase. It is a selective inhibitor of haematopoietic cell proliferation and has antiinflammatory, anti-fibrotic, and pro-angiogenic properties, with particular applications in preventing the development of kidney fibrosis and cardiac fibrosis following injury to these organs.
Mechanism of Action
Ac-SDKP is an endogenous tetrapeptide derivative that is the N-acetylated derivative of the fragment composed of amino acids 1-4 derived from cleavage of the N-terminus of the signalling factor thymosin beta-4 by the enzyme prolyl oligopeptidase. It is a selective inhibitor of haematopoietic cell proliferation and has antiinflammatory, anti-fibrotic, and pro-angiogenic properties, with particular applications in preventing the development of kidney fibrosis and cardiac fibrosis following injury to these organs.
What Researchers Are Saying
Community Reports - Not Medical Advice
The following is aggregated from public forums, Reddit, and research communities. These are anecdotal reports from researchers only - not verified clinical data and not a recommendation of any kind.
Thymosin Beta-4 Fragment (also known as tβ4 fragment, ac-SDKP) is studied within the tissue repair and recovery research community. Tetrapeptide fragment of Thymosin Beta-4 studied for cardiac and tissue protective effects.
Last updated October 28, 2026
Research status: limited. Thymosin Beta-4 Fragment appears across tissue repair and recovery research forums and academic literature. Researchers note this compound falls in the tissue repair category.
Last updated October 28, 2026
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