GLP-1

Key finding: Review lists GLP-1 agonists as future tobacco research direction

In a review covering future directions for tobacco dependence research, the authors included GLP-1 receptor agonists among the newer ideas proposed for further study alongside more established topics in the field.

Jimenez-Ruiz CA, Cristóbal Fernández MI, de Granda-Orive JI, Ramos-Pinedo A, Rábade-Castedo C, Carrion-Valero F, Gorordo-Unzueta I, Riesco-Miranda JA · 2027 · Open respiratory archives · PMID 42892933

Key finding: No clear cognitive change found in Alzheimer trials review

In a review that pooled randomized trials in Alzheimer disease and mild cognitive impairment, researchers reported no clear difference in cognition or progression measures with GLP-1 receptor agonists, and noted adverse events occurred more often in the treatment groups of the included trials.

Siqueira RGP, Ranalli C, Yılmaz D, da Silva M, Maltez BRP, Berton GG, Cummings JL · 2026 · Alzheimer's & dementia (New York, N. Y.) · PMID 42890838

Liskiewicz D, Liskiewicz A, Müller TD · 2026 · Annual review of physiology · PMID 42913426

Pages L, Rojo D, Jimenez-Masip A, Tricarico E, Mas E, Aguilar A, Gomez N, Molinero L, Pericas JM · 2026 · Annals of hepatology · PMID 42918456

Robson SJ · 2026 · BMJ (Clinical research ed.) · PMID 42914157

Key finding: Higher early readmissions noted, longer term outcomes similar

In a human study drawn from a large surgical database, researchers compared shoulder replacement outcomes in adults with obesity who did not have diabetes, and reported higher early readmission rates among those with GLP-1 agonist exposure, with similar outcomes at longer follow up.

Hummel A, Acuña AJ, Hornung A, Lew R, Harkin W, Garrigues GE, Nicholson G · 2026 · Journal of shoulder and elbow arthroplasty · PMID 42892915

Bloomgarden Z · 2026 · Journal of diabetes · PMID 41784368

Key finding: GLP-1 exposure associated with lower atrial fibrillation incidence

In a human study using a large multi center health records network, researchers studied adults without diabetes who had both obesity and kidney disease, and found that GLP-1 receptor agonist exposure was associated with a lower reported occurrence of atrial fibrillation during follow up.

Hassan A, Okorigba E, Grace C, Otabor E, Osineye B, Olayiwola O, Oyeleye T, Amin P · 2026 · International journal of cardiology · PMID 42892471

Key finding: Resisting objectification linked to lower GLP-1 consideration

In a human study of women living in the United Kingdom, researchers measured body image and embodiment traits, and found that resisting objectification was the one trait uniquely associated with lower consideration of GLP-1 medicines.

Schneider J, Garbett KM, Lewis-Smith H, Craddock N · 2026 · Body image · PMID 42892279

Reiszadeh N, Radmanesh R, Heshmat R, Mohammadi H, Darvishi A · 2026 · Journal of diabetes and metabolic disorders · PMID 42894545