Klotho

Lin J, Su L, Yang X, Zhao D, Luo X, Hao L, Liu Y, Wang F · 2027 · Behavioural brain research · PMID 42700933

Uju CN, Unniappan S · 2026 · Theriogenology · PMID 42541973

Key finding: Early terminated trial, no definite conclusion from small sample

A human study evaluated a bispecific antibody engaging FGFR1 and Klotho beta in people with fatty inflammatory liver disease, but early termination and small numbers prevented definite conclusions.

Sanyal AJ, Zou Y, Zhang L, Dash A, Fredrickson J, Gutierrez J, Yoshida K, Liu Y, Kunder R, Wilson M, Wong C · 2026 · JHEP reports : innovation in hepatology · PMID 42892346

Gare SR, Alatawi NH, Chen X, Zhang J, Ross C, Fonseka O, Han Y, Kaur N, Ruiz-Velasco A, Zhao X, Liu Y, Abouleisa RRE · 2026 · Circulation research · PMID 42808145

Kawarazaki W, Ayuzawa N, Nishimoto M, Hirohama D, Ueda K, Marumo T, Fujita T · 2026 · Acta physiologica (Oxford, England) · PMID 42830439

Key finding: Proposed KATP and ERK network with possible Klotho input

A review proposed an integrated gut signaling framework linking energy sensing potassium channels to ERK pathways and discussed FGFR and Klotho signaling as a possible upstream regulator.

Denora M, Di Turi A, Maqoud F, Antonacci M, Orlando A, Drago S, Malerba E, Russo F, Tricarico D · 2026 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · PMID 42892170

Kanbay M, AlShiab R, Shah E, Abdo A, Ortiz A, Mallamaci F, Zoccali C · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · PMID 42886065

Teglas T, Torma F, Bori Z, Aczel D, Babszky G, Kawamura T, Higuchi M, Yaodong G, Lee M, Horvath S, Radak Z · 2026 · GeroScience · PMID 41547678

Hong Y, Wang J, Lu Q, Sun W, Sun J · 2026 · Archives of endocrinology and metabolism · PMID 42905600

Xue K, Wang F, Xi L, Gupta H, Terrill N, Li Y · 2026 · Bone · PMID 42880534