Magainin
Also known as: magainin 1 · magainin 2
For in-vitro (laboratory) research purposes only. Not for human or animal consumption.
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For in-vitro research use only. Not for human consumption.
1What Is Magainin?
Antimicrobial peptide derived from African clawed frog; studied for membrane-disrupting properties and potential anti-cancer applications.
4Published Research - Plain English Summaries
The studies below have been published in peer-reviewed journals. Summaries are written in plain language - no jargon. Citations are provided as text only.
Key finding: Side chain length proved essential for insertion into phospholipid bilayers, the compounds demonstrated activity against clinically relevant pathogens in tests, and early work supported a membrane disrupting method of action.
A 2026 study in the Journal of Medicinal Chemistry explored a series of peptidomimetics inspired by magainin, designed to maintain the membrane disrupting properties of antimicrobial peptides while minimizing breakdown by proteases.
Bergamo D, Cirnski K, Müsken M, Annunziato G, Jézéquel G, Hirsch AKH, Costantino G, Müller R, Pieroni M · 2026 · Journal of medicinal chemistry · PMID 42911731
Vasilescu AM, Vasilescu AG, Sima LE, Munteanu CVA, Baran N, Szedlacsek ȘE · 2025 · Frontiers in pharmacology · PMID 41019995
Khavani M, Mehranfar A, Mofrad MRK · 2025 · Journal of biomolecular structure & dynamics · PMID 38263741
Kim KH, Seo SE, Park CS, Kim S, Lee S, Ryu CM, Yong D, Park YM, Kwon OS · 2022 · Angewandte Chemie (International ed. in English) · PMID 35969510
El-Dirany R, Shahrour H, Dirany Z, Abdel-Sater F, Gonzalez-Gaitano G, Brandenburg K, Martinez de Tejada G, Nguewa PA · 2021 · Biomolecules · PMID 34356608
Li Y, Wu H, Teng P, Bai G, Lin X, Zuo X, Cao C, Cai J · 2015 · Journal of medicinal chemistry · PMID 26020456
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All content on this page is for in-vitro research purposes only. Not intended for human or animal use. Consult a licensed professional before handling research chemicals. No content on this page constitutes medical advice or a treatment recommendation.
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