Neurotensin

Lin X, Li L, Shen Y, Chu X, He A, Li X · 2026 · Cell insight · PMID 42871705

He J, Wang Y, Tang W, Gao X, Cai Y, Tang Y, Hu S · 2026 · Annals of medicine · PMID 42304982

Zhang Y, Yang M, Liu Y, Wang J, Li Q, Yin G, Zhao X · 2026 · Journal of chromatography. A · PMID 42748893

Sun H, Liu X, Zhao X, Zhou Y, Sun H, Zhang J, Li Y, Cao JL, An S · 2026 · Neuron · PMID 42880291

Singh P, Mohanty B · 2026 · International immunopharmacology · PMID 42659935

Key finding: The leading labeled compound demonstrated the most favorable tumor uptake of the designs tested and specificity for NTSR1 in the animals, and it showed antitumor activity without sustained body weight loss.

In an animal study, researchers developed astatine-211 labeled agents targeting neurotensin receptor 1 and tested them in mice carrying HT-29 tumors, using iodine-125 labeled versions for initial design evaluation.

Otsu M, Saito K, Nakashima K, Fujimoto H, Murakami M, Ooe K, Toyoshima A, Watanabe H, Ono M · 2026 · Journal of medicinal chemistry · PMID 42911682

Key finding: After treatment, serum neurotensin and interleukin-6 were significantly lower in the N-acetylcysteine group than in controls, and neuropathy scores were also lower in that group.

In a human study, a randomized controlled trial in colorectal cancer patients receiving FOLFOX chemotherapy, researchers measured serum neurotensin among the biomarkers tracked while testing N-acetylcysteine against chemotherapy related nerve damage.

Hegazy ZK, Tawfik SK, Elmashad NM · 2026 · Cancer chemotherapy and pharmacology · PMID 42909655

Gereau GB, Garrison SD, McElligott ZA · 2023 · Journal of neurochemistry · PMID 37309600

Ferraro L, Tiozzo Fasiolo L, Beggiato S, Borelli AC, Pomierny-Chamiolo L, Frankowska M, Antonelli T, Tomasini MC, Fuxe K, Filip M · 2016 · Journal of psychopharmacology (Oxford, England) · PMID 26755548

Vincent JP, Mazella J, Kitabgi P · 1999 · Trends in pharmacological sciences · PMID 10390649