Sexual HealthActive Research

PT-141

Also known as: pt141 · bremelanotide · vyleesi · melanocortin receptor agonist pt-141 · Bremelanotide · Vyleesi · PT141

For in-vitro (laboratory) research purposes only. Not for human or animal consumption.

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Available Forms

InjectableNasal Spray

Research Applications

Sexual Health

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For in-vitro research use only. Not for human consumption.

1What Is PT-141?

PT-141 (also known as Bremelanotide) is a synthetic analog of the hormone alpha-MSH (alpha-melanocyte-stimulating hormone), which plays a role in the melanocortin system - a network of receptors involved in sexual function, energy balance, and inflammation. PT-141 is specifically a melanocortin receptor 4 (MC4R) agonist. Unlike other compounds that work through vascular mechanisms, PT-141 acts centrally through the nervous system. It was approved by the FDA in 2019 under the name Vyleesi for hypoactive sexual desire disorder (HSDD) in premenopausal women. Research-grade PT-141 is for in-vitro research only.

4What Researchers Have Observed

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Central Nervous System Mechanism

Unlike other compounds in this category, PT-141 works through central melanocortin receptors rather than peripheral vascular pathways, representing a different mechanistic approach that researchers have studied extensively.

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FDA Approval for HSDD

PT-141 (Vyleesi) received FDA approval in 2019 for hypoactive sexual desire disorder (HSDD) in premenopausal women, based on clinical trial data. This makes it one of the few peptides to cross the clinical approval threshold.

These findings are from pre-clinical and early-phase research. Results in human subjects have not been established.

5Published Research - Plain English Summaries

The studies below have been published in peer-reviewed journals. Summaries are written in plain language - no jargon. Citations are provided as text only.

review

Renke G, Chinellato L · 2026 · International journal of molecular sciences · PMID 42123471

review

Hadley ME, Dorr RT · 2006 · Peptides · PMID 16412534

review

Hedlund P · 2004 · Current opinion in investigational drugs (London, England : 2000) · PMID 15134289

human study

Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY · 2003 · Annals of the New York Academy of Sciences · PMID 12851303

6Common Questions

Is PT-141 the same as the FDA-approved drug Vyleesi?↓

Vyleesi is the FDA-approved pharmaceutical formulation (subcutaneous auto-injector, 1.75 mg per dose) approved for a specific medical indication. Research-grade PT-141 is a chemical compound for in-vitro laboratory research only and is not interchangeable with a prescription medication.

How does PT-141 differ from other compounds in its category?↓

Most compounds affecting similar functions work through vascular mechanisms (affecting blood flow). PT-141 works through the central nervous system by activating melanocortin receptors in the brain, representing a fundamentally different mechanism that makes it a useful research tool for studying the neural basis of related functions.

Buy PT-141 - Verified Vendors(21 vendors)

The vendors below are affiliate partners of Peptide Stores Online. Each listing links to the vendor's own website, where ordering, payment, and delivery are handled by the vendor.

Healio Peptides1 listing

PT-141 10mg

PT-141

Available Forms

Research Applications

Check independent lab results, free

1What Is PT-141?

4What Researchers Have Observed

5Published Research - Plain English Summaries

6Common Questions

Buy PT-141 - Verified Vendors(21 vendors)

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