Tissue RepairActive Research

TB-500

Also known as: tb500 · tb 500 · thymosin beta-4 · thymosin beta 4 · tβ4 · tb4 · TB4 · Thymosin B4 · Healing Peptide

For in-vitro (laboratory) research purposes only. Not for human or animal consumption.

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Available Forms

InjectableNasal Spray

Research Applications

Tissue & Wound HealingAnti-InflammatoryMuscle Growth

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For in-vitro research use only. Not for human consumption.

1What Is TB-500?

TB-500, also known as Thymosin Beta-4 (or a synthetic fragment of it), is a peptide derived from a naturally occurring protein found in virtually every cell of the human body. Thymosin Beta-4 plays a key role in regulating actin - a structural protein essential for cell movement, wound healing, and tissue repair. TB-500 is a synthetic fragment of this larger protein, studied in research settings for its potential role in tissue regeneration and anti-inflammatory processes. It is available for laboratory research purposes only.

3How It Works

TB-500 works primarily by upregulating a process called actin polymerization - essentially, it helps cells build and organize the structural "scaffolding" they need to migrate toward wounds and repair damaged tissue. It also appears to promote the formation of new blood vessels (angiogenesis) and may reduce inflammation in injured tissue. In animal studies, it has been shown to accelerate the healing of tendons, ligaments, skin, cardiac tissue, and corneal tissue.

4What Researchers Have Observed

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Muscle & Tendon Healing

Animal studies have shown accelerated healing in muscle injuries and tendon repair models, with improved tissue organization and reduced scar formation.

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Cardiac Research

Early studies in rodent heart attack models showed TB-500 promoted new blood vessel formation and improved cardiac function recovery. This has attracted significant academic interest.

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Corneal Wound Healing

Several studies have examined TB-500's effect on eye injuries, showing accelerated corneal healing and reduced inflammation in animal models.

These findings are from pre-clinical and early-phase research. Results in human subjects have not been established.

5Published Research - Plain English Summaries

The studies below have been published in peer-reviewed journals. Summaries are written in plain language - no jargon. Citations are provided as text only.

review

Mayfield CK, Bolia IK, Feingold CL, Lin EH, Liu JN, Rick Hatch GF, Gamradt SC, Weber AE · 2026 · The American journal of sports medicine · PMID 41476424

review

Rahman OF, Lee SJ, Seeds WA · 2026 · Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · PMID 41490200

animal study

Tewari K, Liu TP, Im C, Hamad C, Petrigliano F, Cheung EC, Kremen TJ · 2026 · The American journal of sports medicine · PMID 42578445

review

Mendias CL, Awan TM · 2026 · Sports medicine (Auckland, N.Z.) · PMID 41966639

animal study

Biçer O, Adanir O, Güleryüz Y, Balci EC, Dinçel YM, Yenigün MY, Aydin C, Bayrak BY · 2026 · Joint diseases and related surgery · PMID 42542926

6Common Questions

Is TB-500 the same as Thymosin Beta-4?↓

Not exactly. TB-500 is a synthetic fragment of Thymosin Beta-4, specifically the actin-binding domain. The full Thymosin Beta-4 protein is a 43-amino-acid peptide; TB-500 is a shorter, more stable version of its key active region. In research, the terms are sometimes used interchangeably but they are technically distinct.

Is TB-500 approved for human use?↓

No. TB-500 is a research chemical not approved by the FDA or any regulatory agency for human use. It is sold exclusively for in-vitro laboratory research.

Buy TB-500 - Verified Vendors(23 vendors)

The vendors below are affiliate partners of Peptide Stores Online. Each listing links to the vendor's own website, where ordering, payment, and delivery are handled by the vendor.

Offline Peptides6 listings

TB-500 5mg

TB-500

Available Forms

Research Applications

Check independent lab results, free

1What Is TB-500?

3How It Works

4What Researchers Have Observed

5Published Research - Plain English Summaries

6Common Questions

Buy TB-500 - Verified Vendors(23 vendors)

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